张桂英,聂磊,中南大学湘雅医院消化内科湖南省长沙市410008聂磊,男,1977-04-22生,江西省樟树人,汉族,2003年中南大学湘雅医学院硕士毕业,现江西省人民医院消化内科住院医师.项目负责人:张桂英,410008,湖南省长沙市湘雅路87号,中南大学湘雅医院消化内科.guiyingzhang@hotmail.com电话:0731-4327249收稿日期:2003-08-07接受日期:2003-11-19LeptinandestrogeninpathogenesisofnonalcoholicfattyliverdiseaseinmaleadultsGui-YingZhang,LeiNieGui-YingZhang,LeiNie,DepartmentofGastroenterology,XiangyaHospital,CentralSouthUniversity,Changsha410008,HunanProvince,ChinaCorrespondenceto:Gui-YingZhang,DepartmentofGastroenterology,XiangyaHospital,CentralSouthUniversity,87XiangyaRoad,Changsha410008,HunanProvince,China.guiyingzhang@hotmail.comReceived:2003-08-07Accepted:2003-11-19AbstractAIM:Toinvestigatetheroleofestrogenandleptininthepathogenesisofnonalcoholicfattyliverdisease（NAFLD）inmaleadults.METHODS:Serumestradiolandleptinweremeasuredbyradioimmunoassay（RIA）inthefollowing3groupsofpatients:obesitywithNAFLD（n=29）,obesity（n=29）,andhealthycontrol（n=29）.RESULTS:Fastinginsulinconcentrationandinsulinresistanceindexcalculatedbyhomeostasismodelassessment（HOMA-IRI）werethehighestinNAFLDgroupwhilethelowestincontrolgroup（P