作者：康东周，赵莲芳，全仙花

［摘要］［目的］研究大豆磷脂对小鼠酒精性肝损伤的保护作用.［方法］建立小鼠酒精性肝损伤模型，设空白对照组、肝损伤模型组和大豆磷脂小、中、大剂量（0.12，0.24，0.48g/kg）组，给予相应处理7d后测定血清中ALT，AST含量和肝匀浆液中MDA，GSH含量.［结果］大豆磷脂大剂量组小鼠血清中ALT含量及中、大剂量大豆磷脂组小鼠血清中AST含量均较肝损伤模型组低，大豆磷脂各剂量组小鼠肝组织内MDA含量显著低于肝损伤模型组，大豆磷脂大剂量组小鼠肝组织内GSH含量明显高于肝损伤模型组.［结论］大豆磷脂对酒精性肝损伤具有保护作用.　　　［关键词］肝疾病，酒精性;植物，药用;小鼠

ABSTRACT:OBJECTIVETostudytheprotectiveeffectsofsoybeanphosphorlipidonethanol-inducedhepatotoxicityinmice.METHODSTheliverinjurymodelswereinducedbyethanolinmice，andwererandomlydividedinto5groups:control，liverinjurycontrolandlow，middle，highdosageofsoybeanphosphorlipidgroups.After7days，thecontentsofALTandASTinserumandtheMDAandGSHinlivertissueweremeasured.RESULTSComparedwithliverinjurycontrolgroup，thecontentsofALTinhighdosageofsoybeanphosphorlipidgroupandtheASTinmiddleandhighdosageofsoybeanphosphorlipidgroupsweredecreasedinserum，thecontentofMDAinlow，middle，highdosageofsoybeanphosphorlipidgroupsweredecreasedinlivertissue，andthecontentofGSHinhighdosageofsoybeanphosphorlipidgroupwasincreasedinlivertissue.CONCLUSIONThesoybeanphosphorlipidhastheprotectiveeffectsonliverinjuriesinducedbyethanolinmice.

Keywords:liverdiseases，alcoholic;plants，medicinal;mice

大豆磷脂含有丰富的磷脂酰胆碱、磷脂酰乙醇胺、磷脂酰肌醇和磷脂酰丝氨酸等成分，脂肪酸组成中不饱和脂肪酸占60%，是一种纯天然的营养保健食品和食品添加剂［1］.大豆磷脂具有降低血脂、预防脂肪肝、提高记忆力、延缓衰老及抗氧化等功能［2～5］.本实验研究了大豆磷脂对酒精性肝损伤小鼠血清ALT，AST和肝组织GSH，MDA含量的影响，探讨大豆磷脂对酒精性肝损伤的保护作用，旨在为大豆磷脂的广泛利用提供理论依据.

1.1.1实验动物&n